AZD 3147

Key Product Details

Product Description

AZD 3147 is a potent and selective dual mTORC1 and 2 inhibitor (IC₅₀ = 1.5 nM). Exhibits >300-fold selectivity for mTOR over PI 3-kinase isoforms. Orally bioavailable.

Product Specifications for AZD 3147

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AZD 3147

The following data is based on the product molecular weight 517.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.93 mL	9.66 mL	19.32 mL
5 mM	0.39 mL	1.93 mL	3.86 mL
10 mM	0.19 mL	0.97 mL	1.93 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Pike Discovery of AZD3147: a potent, selective dual inhibitor of mTORC1 and mTORC2. J.Med.Chem. 2015 PMID: 25643210

Product Documents for AZD 3147