Chemical Name: 3-Amino-4-(1,1-difluoropropyl)-6-[4-(methylsulfonyl)-1-piperidinyl]thieno[2,3-b]pyridine-2-carboxamide
Biological ActivityBI 605906 is a selective IKKβ inhibitor (IC50 = 380 nM). Displays no effect on a panel of 100 kinases, except at IGF1 (IC50 = 7.6 μM).
External Portal InformationThe Chemical Probes webpages of the Structural Genomics Consortium are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BI 605906 is reviewed on the chemical probes website.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Novel cross-talk within the IKK family controls innate immunity.
Clark et al.
An unexpected twist to the activation of IKKβ: TAK1 primes IKK� for activation by autophosphorylation.
Zhang et al.
Citations for BI 605906
The citations listed below are publications that use Tocris products. Selected citations for BI 605906 include:
3 Citations: Showing 1 - 3
Impact of retrotransposon protein L1 ORF1p expression on oncogenic pathways in hepatocellular carcinoma: the role of cytoplasmic PIN1 upregulation.
Authors: Derek A Et al.
Br J Cancer 2023;128:1236-1248
The PI3K/mTOR inhibitor Gedatolisib eliminates dormant breast cancer cells in organotypic culture, but fails to prevent metastasis in preclinical settings.
Authors: Mina J Et al.
Mol Oncol 2022;16:130-147
Syntaxin 4 Mediates NF-κB Signaling and Chemokine Ligand Expression via Specific Interaction With IκBβ.
Authors: Diti Et al.
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