Home / IkB Kinase Inhibitors / BI 605906

BI 605906

Catalog #: 5300
3 Citations Datasheet / COA / SDS

Discontinued Product

5300 has been discontinued.
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BI 605906 | CAS No. 960293-88-3 | IkB Kinase Inhibitors
1 Image
Description: Selective IKKβ inhibitor

Chemical Name: 3-Amino-4-(1,1-difluoropropyl)-6-[4-(methylsulfonyl)-1-piperidinyl]thieno[2,3-b]pyridine-2-carboxamide

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

BI 605906 is a selective IKKβ inhibitor (IC50 = 380 nM). Displays no effect on a panel of 100 kinases, except at IGF1 (IC50 = 7.6 μM).

External Portal Information

The Chemical Probes webpages of the Structural Genomics Consortium are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BI 605906 is reviewed on the chemical probes website.

Technical Data

M.Wt:
432.51
Formula:
C17H22F2N4O3S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
960293-88-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for BI 605906

The citations listed below are publications that use Tocris products. Selected citations for BI 605906 include:

3 Citations: Showing 1 - 3

  1. Impact of retrotransposon protein L1 ORF1p expression on oncogenic pathways in hepatocellular carcinoma: the role of cytoplasmic PIN1 upregulation.
    Authors: Derek A Et al.
    Br J Cancer  2023;128:1236-1248
  2. The PI3K/mTOR inhibitor Gedatolisib eliminates dormant breast cancer cells in organotypic culture, but fails to prevent metastasis in preclinical settings.
    Authors: Mina J Et al.
    Mol Oncol  2022;16:130-147
  3. Syntaxin 4 Mediates NF-κB Signaling and Chemokine Ligand Expression via Specific Interaction With IκBβ.
    Authors: Diti Et al.
    Diabetes  2021;70:889-902

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