BMS 191011

Tocris Bioscience | Catalog # 2665

Potent KCa1.1 (BK) channel opener
Tocris Bioscience

Key Product Details

Description

Potent KCa1.1 (BK) channel opener
View all Ca2+-Activated Potassium Channel Activators »

Product Description

BMS 191011 is a potent BKCa channel opener (large-conductance Ca2+-activated potassium channel, KCa1.1). Neuroprotectant in two distinct animal models of stroke (MCAO in the SHR rat and a normotensive model of focal stroke).

Product Specifications for BMS 191011

Molecular Weight

370.71

Formula

C16H10ClF3N2O3

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one

CAS Number

202821-81-6

PubChem ID

10474339

InChI Key

QKOWACXSXTXRKA-UHFFFAOYSA-N

SMILES

OC1=CC=C(Cl)C=C1CN1N=C(OC1=O)C1=CC=C(C=C1)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.07 100

Preparing Stock Solutions for BMS 191011

The following data is based on the product molecular weight 370.71.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.70 mL 13.49 mL 26.98 mL
5 mM 0.54 mL 2.70 mL 5.40 mL
10 mM 0.27 mL 1.35 mL 2.70 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

Product Documents for BMS 191011

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BMS 191011

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for BMS 191011 (1)

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  • BK channel activator with great research potential
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HEK 293
    Verified Customer | Posted 10/29/2018
    Dissolve in DMSO
    The product was used to study BK channels expressed in brain. It shows moderate channel opening, works well in expperimental conditions and is stable.
    BMS 191011 2665

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