BMS CCR2 22

Tocris Bioscience | Catalog # 3129

High affinity, potent CCR2 antagonist
Tocris Bioscience

Key Product Details

Description

High affinity, potent CCR2 antagonist
View all Chemokine Receptor Antagonists »

Product Description

BMS CCR2 22 is a high affinity CCR2 chemokine receptor antagonist (IC50 = 5.1 nM). Displays potent functional antagonism, IC50 values are 1 and 18 nM for chemotaxis and antagonism of calcium flux respectively. Selective over CCR3.

Product Specifications for BMS CCR2 22

Molecular Weight

593.66

Formula

C28H34F3N5O4S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-[(Isopropylaminocarbonyl)amino]-N-[2-[[cis-2-[[4-(methylthio)benzoyl]amino]cyclohexyl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide

CAS Number

445479-97-0

PubChem ID

24801690

InChI Key

IBPXYDUJQWENPM-XZOQPEGZSA-N

SMILES

O=C(N[C@@H]2CCCC[C@@H]2NC(CNC(C3=C(NC(NC(C)C)=O)C=CC(C(F)(F)F)=C3)=O)=O)C1=CC=C(SC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 59.37 100
Ethanol 5.94 10

Preparing Stock Solutions for BMS CCR2 22

The following data is based on the product molecular weight 593.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.68 mL 8.42 mL 16.84 mL
5 mM 0.34 mL 1.68 mL 3.37 mL
10 mM 0.17 mL 0.84 mL 1.68 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 25 publications citing the usage of this product.

Product Documents for BMS CCR2 22

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BMS CCR2 22

For research use only

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