28 results for "Chemokine Receptor Antagonists" in 产品
Chemokine Receptor Antagonists
Chemokine receptors are found predominantly on leukocytes and are important in leukocyte trafficking, as well as leukocyte-dependent processes such as immune surveillance, immune response and pathological inflammation. Chemokines have a role in angiogenesis, apoptosis, T-cell differentiation and phagocyte activation, while inappropriate or prolonged expression of chemokines and their receptors can lead to autoimmune disease by incorrectly targeting self antigens for destruction by cytotoxic ...
Highly selective CCR2 chemokine receptor antagonist
| Chemical Name: | 6-Methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one |
| Purity: | ≥98% |
Highly selective CXCR4 antagonist
| Alternate Names: | JM 3100,Plerixafor |
| Chemical Name: | 1,1'-[1,4-Phenylenebis-(methylene)]-bis-(1,4,8,11-tetraazacyclotetradecane) octahydrochloride |
Selective CCR5 antagonist
| Alternate Names: | UK-427857 |
| Chemical Name: | 4,4-Difluoro-N-{(1S)-3-[3-(3-isopropyl- 5-methyl-4H-1,2,4-triazol-4-yl)- 8-azabicyclo[3.2.1]oct-8-yl]-1- phenylpropyl}cyclohexanecarboxamide |
| Purity: | ≥98% |
Potent and selective CCR3 antagonist
| Chemical Name: | N-(1-Naphthalenylcarbonyl)-4-nitro-L-phenylalanine methyl ester |
| Purity: | ≥98% |
CXCR3 antagonist; inhibits cell migration and metastasis
| Chemical Name: | N-1-[(3-4(-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(3-pyridinylmethyl)-4-(trifluoromethoxy)benzeneacetamide |
| Purity: | ≥98% |
Potent and selective CXCR2 antagonist
| Chemical Name: | N-(2-Bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)urea |
| Purity: | ≥98% |
High affinity, potent CCR2 antagonist
| Chemical Name: | 2-[(Isopropylaminocarbonyl)amino]-N-[2-[[cis-2-[[4-(methylthio)benzoyl]amino]cyclohexyl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide |
| Purity: | ≥98% |
Potent CXCR2 antagonist
| Chemical Name: | N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea |
| Purity: | ≥98% |
CCR2b chemokine receptor antagonist
| Chemical Name: | 1'-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one hydrochloride |
| Purity: | ≥98% |
Selective CCR1 antagonist
| Alternate Names: | VUF 2274 |
| Chemical Name: | 4-(4-Chlorophenyl)-4-hydroxy-α,α-diphenyl-1-piperidinepentanenitrile hydrochloride |
| Purity: | ≥98% |
Potent and selective CXCR4 antagonist
| Chemical Name: | N-[[4-(1,4,8,11-Tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-pyridinemethanamine hexahydrobromide |
| Purity: | ≥97% |
Potent and selective CXCR3 antagonist
| Chemical Name: | N-1-[(3-4(-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-4-fluoro-N-(3-pyridinylmethyl)-3-(trifluoromethyl)benzeneacetamide |
| Purity: | ≥98% |
Potent CCR1 chemokine receptor antagonist
| Chemical Name: | 1,4-cis-1-(1-Cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethylpiperidinium iodide |
| Purity: | ≥98% |
Potent CCR1 and CCR3 antagonist
| Chemical Name: | 1,4-trans-1-(1-Cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethylpiperidinium iodide |
| Purity: | ≥98% |
Potent CXCR4 antagonist
| Chemical Name: | N,N'-Dicyclohexylcarbamimidothioic acid (5,6-dihydro-6,6-dimethylimidazo[2,1-b]thiazol-3-yl)methyl ester dihydrochloride |
| Purity: | ≥98% |
CXCR4 antagonist; antitumor
| Purity: | ≥95% |
Potent, selective CCR1 antagonist
| Alternate Names: | ZK-811752 |
| Chemical Name: | (2R)-1-[[2-[(Aminocarbonyl)amino]-4-chlorophenoxy]acetyl]-4-[(4-fluorophenyl)methyl]-2-methylpiperazine |
| Purity: | ≥98% |
Potent CCR4 antagonist
| Chemical Name: | 2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine dihydrochloride |
| Purity: | ≥98% |
Potent and selective CCR3 antagonist
| Chemical Name: | N-Benzoyl-4-nitroaniline ethyl ester |
| Purity: | ≥98% |
Selective CCR2 antagonist
| Chemical Name: | N-[2-[[(3R)-1-[trans-4-Hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-benzamide dimethanesulfonate |
| Purity: | ≥98% |
Potent CXCR2 antagonist
| Chemical Name: | 6-Chloro-3-[[[(2,3-dichlorophenyl)amino]carbonyl]amino]-2-hydroxybenzenesulfonamide |
| Purity: | ≥98% |
Potent and selective CCR5 and CCR2 chemokine receptor antagonist
| Chemical Name: | N-[[4-[[[6,7-Dihydro-2-(4-methylphenyl)-5H-benzocyclohepten-8-yl]carbonyl]amino]phenyl]methyl]tetrahydro-N,N-dimethyl-2H-pyran-4-aminium chloride |
| Purity: | ≥98% |
Potent CXCR2 antagonist
| Chemical Name: | 5-[[(3-Chloro-2-fluorophenyl)methyl]thio]-7-[[(1R)-2-hydroxy-1-methylethyl]amino]thiazolo[4,5-d]pyrimidin-2(3H)-one |
| Purity: | ≥98% |
Potent and selective hCXCR6 antagonist
| Chemical Name: | N-[(1R,3S,5S)-9-(2-((2-Chlorophenyl)amino)-2-exoethyl)-9-azabicyclo[3.3.1]nonan-3-yl)-3,4,5-trimethoxybenzamide |
| Purity: | ≥98% |
Potent and selective CCR10 antagonist
| Chemical Name: | N-[(1R)-3-(2-Cyano-1H-pyrrol-1-yl)-1-[(4-methyl-1-piperidinyl)carbonyl]propyl]-1H-indole-4-sulfonamide |
| Purity: | ≥98% |
