BSJ-03-123

Tocris Bioscience | Catalog # 6921

Selective Cdk6 Degrader (PROTAC®)
Tocris Bioscience

Key Product Details

Description

Selective Cdk6 Degrader (PROTAC®)
View all Active Degraders »

Product Description

BSJ-03-123 is a selective Cdk6 Degrader (PROTAC®) (DC50 in sub 10 μM range). Displays no degradation of closely related Cdk4.

Negative control BSJ-Bump (Cat. No. 6922) and Cdk6 antibody validated for Western Blot also available: Catalog # NBP1-87262.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Product Specifications for BSJ-03-123

Molecular Weight

937.02

Formula

C47H56N10O11

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[2-[2-[2-[2-[4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]ethoxy]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide

CAS Number

2361493-16-3

PubChem ID

137628658

InChI Key

LUHCYAOYQIFNRN-UHFFFAOYSA-N

SMILES

O=C1N(C2=NC(NC3=CC=C(C=N3)N4CCN(CCOCCOCCOCCNC(COC5=C(C(N(C6C(NC(CC6)=O)=O)C7=O)=O)C7=CC=C5)=O)CC4)=NC=C2C(C)=C1C(C)=O)C8CCCC8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 93.7 100

Preparing Stock Solutions for BSJ-03-123

The following data is based on the product molecular weight 937.02.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.07 mL 5.34 mL 10.67 mL
5 mM 0.21 mL 1.07 mL 2.13 mL
10 mM 0.11 mL 0.53 mL 1.07 mL
50 mM 0.02 mL 0.11 mL 0.21 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for BSJ-03-123

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BSJ-03-123

For research use only

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