BSJ-4-116

Tocris Bioscience | Catalog # 7528

Selective CDK12 PROTAC® Degrader
Tocris Bioscience

Key Product Details

Description

Selective CDK12 PROTAC® Degrader
View all Active Degraders »

Product Description

BSJ-4-116 is a selective CDK12 PROTAC® Degrader. BSJ-4-116 selectively degrades CDK12 over a panel of other kinases and exhibits no degradation of CDK13 or cyclin K. The compound inhibits growth of T-ALL cells and sensitizes them to PARP inhibitor Olaparib (Cat. No. 7579).

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Product Specifications for BSJ-4-116

Molecular Weight

837.39

Formula

C40H49ClN8O8S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[7-[(3R)-3-[[5-Chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-1-piperidinyl]heptyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide

CAS Number

2519823-34-6

PubChem ID

155235839

InChI Key

YJOJMGTVKMABKQ-FIQOPJFZSA-N

SMILES

CC(S(=O)(C1=C(C=CC=C1)NC2=NC(N[C@@H]3CCCN(C3)CCCCCCCNC(COC4=C5C(N(C(C5=CC=C4)=O)C6CCC(NC6=O)=O)=O)=O)=NC=C2Cl)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 83.74 100

Preparing Stock Solutions for BSJ-4-116

The following data is based on the product molecular weight 837.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.19 mL 5.97 mL 11.94 mL
5 mM 0.24 mL 1.19 mL 2.39 mL
10 mM 0.12 mL 0.60 mL 1.19 mL
50 mM 0.02 mL 0.12 mL 0.24 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for BSJ-4-116

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BSJ-4-116

For research use only

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