Cambinol

Key Product Details

Product Description

Cambinol is a neutral sphingomyelinase-2 (nSMase2) inhibitor (K_i = 7 μM; IC₅₀ ~ 7.7 μM). In vitro, Cambinol suppresses extracellular vesicle production and inhibits cell-to-cell tau propagation in tau biosensor cells. In vivo, Cambinol decreases tumor necrosis factor-α or interleukin-1β-induced increases of ceramide and cell death in primary neurons. Cambinol is neuroprotective and brain penetrant. Cambinol inhibits the activity of human SIRT1 and SIRT2 and exerts antitumor activity in vitro and in mouse xenograft studies.

Product Specifications for Cambinol

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Cambinol

The following data is based on the product molecular weight 360.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.77 mL	13.87 mL	27.74 mL
5 mM	0.55 mL	2.77 mL	5.55 mL
10 mM	0.28 mL	1.39 mL	2.77 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Heltweg Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res. 2006 PMID: 16618762
• Bilousova Suppression of tau propagation using an inhibitor that targets the DK-switch of nSMase2. Biochem.Biophys.Res.Commun. 2018 PMID: 29604274
• Stepanek Neutral sphingomyelinase 2 inhibitors based on the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold. Eur.J.Med.Chem. 2019 PMID: 30921693
• Sackmann Inhibition of nSMase2 reduces the transfer of oligomeric α-synuclein irrespective of hypoxia. Front.Mol.Neurosci. 2019 PMID: 31555088
• Figuera-Losada Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties. PLoS One 2015 PMID: 26010541

Product Documents for Cambinol