Capsazepine

Key Product Details

Product Description

Capsazepine is a selective vanilloid receptor antagonist (K_i = 3.2 μM). Inhibits carrageenan inflammation-induced hyperalgesic responses in the rat. Also activates amiloride-sensitive epithelial Na⁺ channel ENaCδ.

Product Specifications for Capsazepine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Capsazepine

The following data is based on the product molecular weight 376.90.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

8 7 6 5 4 3 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.65 mL	13.27 mL	26.53 mL
5 mM	0.53 mL	2.65 mL	5.31 mL
10 mM	0.27 mL	1.33 mL	2.65 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 250 publications citing the usage of this product.

• Kwak A capsaicin-receptor antagonist, capsazepine, reduces inflammation-induced hyperalgesic responses in the rat: evidence for an endogenous capsaicin-like substance. Neuroscience 1998 PMID: 9881874
• Yamamura Capsazepine is a novel activator of the δ subunit of the human epithelial Na⁺ channel. J.Biol.Chem. 2004 PMID: 15308635
• Dickenson and Dray Selective antagonism of capsaicin by capsazepine: evidence for a spinal receptor site in capsaicin-induced antinociception. Br.J.Pharmacol. 1991 PMID: 1810591

Product Documents for Capsazepine