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Caspase-3 Fluorometric Assay Kit

Catalog #: K105-100
26 Citations Datasheet / COA / SDS

Discontinued Product

K105-100 has been discontinued.
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Citations (26)
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Caspase-3 Fluorometric Assay Kit Summary

Specifications

Source
N/A
Shipping Conditions
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Multi-Species

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Background: Caspase-3

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).

Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.

Entrez Gene IDs
836 (Human); 12367 (Mouse)
Alternate Names
Apopain; apoptosis-related cysteine protease; CASP3; CASP-3; caspase 3, apoptosis-related cysteine peptidase; Caspase3; Caspase-3; CPP32; CPP-32; CPP32B; CPP32SREBP cleavage activity 1; Cysteine protease CPP32; EC 3.4.22; EC 3.4.22.56; LICE-1; PARP cleavage protease; procaspase3; Protein Yama; SCA-1; YAMA

Citations for Caspase-3 Fluorometric Assay Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

26 Citations: Showing 1 - 10
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  1. Gaillardin, a potent sesquiterpene lactone induces apoptosis via down-regulation of NF-kappabeta in gastric cancer cells, AGS and MKN45
    Authors: M Roozbehani, MH Abdolmoham, M Hamzeloo-M, S Irani, F Fallahian
    Journal of ethnopharmacology, 2021-08-19;0(0):114529.  2021-08-19
  2. MICA-G129R: A bifunctional fusion protein increases PRLR-positive breast cancer cell death in co-culture with natural killer cells
    Authors: H Ding, GW Buzzard, S Huang, MG Sehorn, RK Marcus, Y Wei
    PLoS ONE, 2021-06-02;16(6):e0252662.  2021-06-02
  3. Withaferin A Prevents Myocardial Ischemia/Reperfusion Injury by Upregulating AMP-Activated Protein Kinase-Dependent B-Cell Lymphoma2 Signaling
    Authors: R Guo, L Gan, WB Lau, Z Yan, D Xie, E Gao, TA Christophe, BL Lopez, X Ma, Y Wang
    Circ. J., 2019-06-20;0(0):.  2019-06-20
  4. High Glucose-Mediated Tyrosine Nitration of PI3-Kinase: A Molecular Switch of Survival and Apoptosis in Endothelial Cells
    Authors: SL Elshaer, T Lemtalsi, AB El-Remessy
    Antioxidants (Basel), 2018-03-25;7(4):.  2018-03-25
  5. Neutralization of CD95 ligand protects the liver against ischemia-reperfusion injury and prevents acute liver failure
    Authors: M Al-Saeedi, N Steinebrun, H Kudsi, N Halama, C Mogler, MW Büchler, PH Krammer, P Schemmer, M Müller
    Cell Death Dis, 2018-01-26;9(2):132.  2018-01-26
  6. Curcumin protects cortical neurons against oxygen and glucose deprivation/reoxygenation injury through flotillin-1 and extracellular signal-regulated kinase1/2 pathway
    Authors: Z Lu, Y Liu, Y Shi, X Shi, X Wang, C Xu, H Zhao, Q Dong
    Biochem. Biophys. Res. Commun., 2018-01-17;496(2):515-522.  2018-01-17
  7. miR-495 sensitizes MDR cancer cells to the combination of doxorubicin and taxol by inhibiting MDR1 expression
    Authors: Z Zou, R Zou, D Zong, Y Shi, J Chen, J Huang, J Zhu, L Chen, X Bao, Y Liu, W Liu, W Huang, J Hu, Z Chen, X Lao, C Chen, X Huang, Y Lu, X Ni, D Fang, D Wu, S Lu, M Jiang, C Qiu, Y Wu, Q Qiu, Y Dong, Y Su, C Zhao, Z Zhong, J Cai, Y Liang
    J. Cell. Mol. Med., 2017-04-14;0(0):.  2017-04-14
  8. Sulforaphane sensitizes human breast cancer cells to paclitaxel-induced apoptosis by downregulating the NF-?B signaling pathway
    Authors: SH Kim, HJ Park, DO Moon
    Oncol Lett, 2017-03-29;13(6):4427-4432.  2017-03-29
  9. Ceramide Is Metabolized to Acylceramide and Stored in Lipid Droplets
    Authors: CE Senkal, MF Salama, AJ Snider, JJ Allopenna, NA Rana, A Koller, YA Hannun, LM Obeid
    Cell Metab, 2017-03-07;25(3):686-697.  2017-03-07
  10. Endothelial cell colony forming units derived from malignant breast diseases are resistant to tumor necrosis factor-?-induced apoptosis
    Sci Rep, 2016-11-24;6(0):37450.  2016-11-24
  11. Pemetrexed induces S-phase arrest and apoptosis via a deregulated activation of Akt signaling pathway.
    Authors: Chen K, Yang T, Wu C, Cheng C, Hsu S, Hung H, Chen J, Chang G
    PLoS ONE, 2014-05-21;9(5):e97888.  2014-05-21
  12. MUC16 mucin (CA125) attenuates TRAIL-induced apoptosis by decreasing TRAIL receptor R2 expression and increasing c-FLIP expression.
    Authors: Matte I, Lane D, Boivin M, Rancourt C, Piche A
    BMC Cancer, 2014-04-01;14(0):234.  2014-04-01
  13. MCL-1ES induces MCL-1L-dependent BAX- and BAK-independent mitochondrial apoptosis.
    Authors: Kim, Jae-Hong, Bae, Jeehyeon
    PLoS ONE, 2013-11-18;8(11):e79626.  2013-11-18
  14. Complement factor B is the downstream effector of TLRs and plays an important role in a mouse model of severe sepsis.
    Authors: Zou, Lin, Feng, Yan, Li, Yan, Zhang, Ming, Chen, Chan, Cai, Jiayan, Gong, Yu, Wang, Larry, Thurman, Joshua M, Wu, Xiaobo, Atkinson, John P, Chao, Wei
    J Immunol, 2013-10-23;191(11):5625-35.  2013-10-23
  15. Cytoplasmic redistribution and cleavage of AUF1 during coxsackievirus infection enhance the stability of its viral genome.
    Authors: Wong, Jerry, Si, Xiaoning, Angeles, Arkhjami, Zhang, Jingchun, Shi, Junyan, Fung, Gabriel, Jagdeo, Julienne, Wang, Tianying, Zhong, Zhaohua, Jan, Eric, Luo, Honglin
    FASEB J, 2013-04-09;27(7):2777-87.  2013-04-09
  16. A novel synthetic microtubule inhibitor, MPT0B214 exhibits antitumor activity in human tumor cells through mitochondria-dependent intrinsic pathway.
    Authors: Chiang, Nai-Jung, Lin, Ching-I, Liou, Jing-Pin, Kuo, Ching-Ch, Chang, Chi-Yen, Chen, Li-Tzong, Chang, Jang-Yan
    PLoS ONE, 2013-03-12;8(3):e58953.  2013-03-12
  17. Tumor cells expressing a fusion protein of MULT1 and Fas are rejected in vivo by apoptosis and NK cell activation.
    Authors: Kotturi HS, Li J, Branham-O'Connor M, Stickel SL, Yu X, Wagner TE, Wei Y
    Gene Ther., 2008-05-08;15(19):1302-10.  2008-05-08
  18. Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway.
    Authors: Su YT, Chang HL, Shyue SK, Hsu SL
    Biochem. Pharmacol., 2005-07-15;70(2):229-41.  2005-07-15
  19. Enhanced 15-HPETE production during oxidant stress induces apoptosis of endothelial cells.
    Authors: Sordillo LM, Weaver JA, Cao YZ, Corl C, Sylte MJ, Mullarky IK
    Prostaglandins Other Lipid Mediat., 2005-05-01;76(1):19-34.  2005-05-01
  20. Anti-proliferative activity of Bupleurum scrozonerifolium in A549 human lung cancer cells in vitro and in vivo.
    Authors: Cheng YL, Lee SC, Lin SZ, Chang WL, Chen YL, Tsai NM, Liu YC, Tzao C, Yu DS, Harn HJ
    Cancer Lett., 2004-11-19;222(2):183-93.  2004-11-19
  21. Norepinephrine induces apoptosis in neonatal rat cardiomyocytes through a reactive oxygen species-TNF alpha-caspase signaling pathway.
    Authors: Fu YC, Chi CS, Yin SC, Hwang B, Chiu YT, Hsu SL
    Cardiovasc. Res., 2004-06-01;62(3):558-67.  2004-06-01
  22. IFN-beta induces caspase-mediated apoptosis by disrupting mitochondria in human advanced stage colon cancer cell lines.
    Authors: Juang SH, Wei SJ, Hung YM, Hsu CY, Yang DM, Liu KJ, Chen WS, Yang WK
    J. Interferon Cytokine Res., 2004-04-01;24(4):231-43.  2004-04-01
  23. Norepinephrine induces apoptosis in neonatal rat endothelial cells via down-regulation of Bcl-2 and activation of beta-adrenergic and caspase-2 pathways.
    Authors: Fu YC, Chi CS, Yin SC, Hwang B, Chiu YT, Hsu SL
    Cardiovasc. Res., 2004-01-01;61(1):143-51.  2004-01-01
  24. Effector mechanisms of norcantharidin-induced mitotic arrest and apoptosis in human hepatoma cells.
    Authors: Chen YN, 2019, Chen JC, Yin SC, Wang GS, Tsauer W, Hsu SF, Hsu SL
    7020, 2002-07-10;100(2):158-65.  2002-07-10
  25. Age-associated increases in the activity of multiple caspases in Fisher 344 rat organs.
    Authors: Zhang Y, 107275, Chong E, Herman B
    Acute Infection with a Tobramycin-Induced Small Colony Variant of Staphylococcus aureus Causes Increased Inflammation in the Cystic Fibrosis Rat Lung, 2002-06-01;37(6):777-89.  2002-06-01
  26. Induction of DNA breaks and apoptosis in crosslink-hypersensitive V79 cells by the cytostatic drug beta-D-glucosyl-ifosfamide mustard.
    Authors: Becker R, Ritter A, Eichhorn U, Lips J, Bertram B, Wiessler M, Zdzienicka MZ, Kaina B
    Br. J. Cancer, 2002-01-07;86(1):130-5.  2002-01-07

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