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Clemizole hydrochloride

Catalog #: 5371
3 Citations Datasheet / COA / SDS
Newer Version Available: 6766
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Discontinued Product

5371 has been discontinued and is replaced by 6766.

Clemizole hydrochloride | CAS No. 1163-36-6 | TRPC Channel Blockers
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Description: TRPC5 blocker; also H1 antagonist

Chemical Name: 1-[(4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole hydrochloride

Purity: ≥99%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

TRPC5 channel blocker (IC50 values are 1.1, 6.4, 9.1, 11.3 and 26.5 μM for TRPC5, TRPC4, TRPC3, TRPC6 and TRPC7 respectively). Exhibits minimal effect on TRPM3, TRPM8 and TRPV1-4 channels. Also histamine H1 receptor antagonist and anticonvulsant in zebrafish Dravet syndrome model.

Technical Data

M.Wt:
362.3
Formula:
C19H20ClN3. HCl
Solubility:
Soluble to 20 mM in water and to 50 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
1163-36-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for Clemizole hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Clemizole hydrochloride include:

3 Citations: Showing 1 - 3

  1. DA Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of DA and Glutamate.
    Authors: Cai and Ford
    Cell Rep  2018;25:3148
  2. Activation of TREK currents by riluzole in three subgroups of cultured mouse nodose ganglion neurons.
    Authors: Fernandez-Fernandez Et al.
    PLoS One  2018;13:e0199282
  3. Subcutaneous white adipocytes express a light sensitive signaling pathway mediated via a melanopsin/TRPC channel axis.
    Authors: Ondrusova Et al.
    Sci Rep  2017;7:16332

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