AC 1903

Key Product Details

Product Description

AC 1903 is a selective TRPC5 blocker (IC₅₀ = 4.0 - 13.6 μM). Also displays weak inhibition at TRPC4 (IC₅₀ >100 μM) but not TRPC6. Exhibits no effect against a standard panel of profiling kinases. Blocks TRPC5 channel activity in glomeruli of proteinuric rats. Suppresses severe proteinuria and prevents podocyte loss in a transgenic rat model of focal segmental glomerulosclerosis (FSGS).

Product Specifications for AC 1903

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AC 1903

The following data is based on the product molecular weight 303.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.59 mL	32.96 mL	65.93 mL
2.5 mM	1.32 mL	6.59 mL	13.19 mL
5 mM	0.66 mL	3.30 mL	6.59 mL
25 mM	0.13 mL	0.66 mL	1.32 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Sharma Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903. Bioorg.Med.Chem.Lett. 2019 PMID: 30538066
• Zhou A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models. Science 2017 PMID: 29217578
• Minard Remarkable progress with small-molecule modulation of TRPC1/4/5 channels: implications for understanding the channels in health and disease. Cells 2018 PMID: 29865154
• Chung TRP'ing up chronic kidney disease. Science 2017 PMID: 29217557

Product Documents for AC 1903