AC 1903

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AC 1903 | CAS No. 831234-13-0 | TRPC Channel Blockers
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Description: Selective TRPC5 inhibitor

Chemical Name: N-(2-Furanylmethyl)-1-(phenylmethyl)-1H-benzimidazol-2-amine

Purity: ≥98%

Product Details

Biological Activity

AC 1903 is a selective TRPC5 blocker (IC50 = 13.6 μM). Also displays weak inhibition at TRPC4 (IC50 >100 μM) but not TRPC6. Exhibits no effect against a standard panel of profiling kinases. Blocks TRPC5 channel activity in glomeruli of proteinuric rats. Suppresses severe proteinuria and prevents podocyte loss in a transgenic rat model of focal segmental glomerulosclerosis (FSGS).

Technical Data

Soluble to 50 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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