AC 1903

Catalog # Availability Size / Price Qty
6766/5
6766/25

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AC 1903 | CAS No. 831234-13-0 | TRPC Channel Blockers
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Description: Selective TRPC5 inhibitor

Chemical Name: N-(2-Furanylmethyl)-1-(phenylmethyl)-1H-benzimidazol-2-amine

Purity: ≥98%

Product Details
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Biological Activity

AC 1903 is a selective TRPC5 blocker (IC50 = 13.6 μM). Also displays weak inhibition at TRPC4 (IC50 >100 μM) but not TRPC6. Exhibits no effect against a standard panel of profiling kinases. Blocks TRPC5 channel activity in glomeruli of proteinuric rats. Suppresses severe proteinuria and prevents podocyte loss in a transgenic rat model of focal segmental glomerulosclerosis (FSGS).

Technical Data

M.Wt:
303.36
Formula:
C19H17N3O
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
831234-13-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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