CM 11

Tocris Bioscience | Catalog # 6416

Homo-PROTAC® for self-degradation of pVHL30
Tocris Bioscience

Key Product Details

Description

Homo-PROTAC® for self-degradation of pVHL30
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Product Description

CM 11 is a PROTAC® for self-degradation of the long form of VHL, pVHL30 (DC50 < 100 nM). Composed of two VHL ligands joined by a linker. Exhibits > 1000-fold increased cellular activity compared to the parent VHL ligand, VH 032. Dimerizes pVHL30 with high avidity in vitro. Induced potent and rapid self-degradation of VHL in cell lines in a highly isoform dependent fashion. Negative control CMP 98 (Cat. No. 6417) also available.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under licence from the University of Dundee

Product Specifications for CM 11

Molecular Weight

1179.46

Formula

C58H82N8O14S2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N1,N20-bis((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15,18-hexaoxaicosanediamide

CAS Number

2244684-49-7

PubChem ID

134160242

InChI Key

WGJCHHJGGFCCRS-DEYDLUNASA-N

SMILES

CC1=C(C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@H](C(C)(C)C)NC(COCCOCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)=O)=O)C=C2)SC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 117.95 100

Preparing Stock Solutions for CM 11

The following data is based on the product molecular weight 1179.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.85 mL 4.24 mL 8.48 mL
5 mM 0.17 mL 0.85 mL 1.70 mL
10 mM 0.08 mL 0.42 mL 0.85 mL
50 mM 0.02 mL 0.08 mL 0.17 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for CM 11

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CM 11

For research use only

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