Compound E

Tocris Bioscience | Catalog # TB6476-RMU

Compound E synthesized to Ancillary Material Grade
Tocris Bioscience

Key Product Details

Description

Compound E synthesized to Ancillary Material Grade

Alternative Names

γ-Secretase Inhibitor XXI
View all Ancillary Material Grade Compounds »

Product Description

Compound E is a γ-secretase and notch pathway inhibitor. Compound E enhances growth inhibition, differentiation and migration of neuroblastoma cells when used in a combination with DAPT (Cat. No. 2634) and 13-cis RA. In combination with hLIF, CHIR 99021 (Cat. No. 4423) and SB 431542 (Cat. No. 1614), Compound E accelerates the induction of a homogeneous, self-renewing primitive neuroepithelium population from hESCs. Compound E is active in vitro and in vivo. Used in protocol to generate pancreatic beta cells from hPSCs (see below).

For more information about how Compound E may be used, see our protocol: Generation of β cells from hPSCs

This product is Bio-Techne's ancillary Material Grade version of Compound E (Cat. No. 6476). Suitable for use in research and further manufacturing of cell therapies. Find out more about our Ancillary Material Grade product range.

Product Specifications for Compound E

Molecular Weight

490.50

Formula

C27H24F2N4O3

Storage

Store at -20°C (± 5°C)

Purity

≥98%

Chemical Name

N-[(1S)-2-[[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide

CAS Number

209986-17-4

InChI Key

JNGZXGGOCLZBFB-IVCQMTBJSA-N

SMILES

C[C@@H](C(N[C@H]1N=C(C2=CC=CC=C2N(C1=O)C)C3=CC=CC=C3)=O)NC(CC4=CC(F)=CC(F)=C4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

There are currently no references for this product.

Product Documents for Compound E

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Compound E

For research use only

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