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Cromakalim

Catalog #: 1377
7 Citations Datasheet / COA / SDS

Discontinued Product

1377 has been discontinued.
View all Inward Rectifier Potassium Channel Activators products.
Cromakalim | CAS No. 94470-67-4 | Inward Rectifier Potassium Channel Activators
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Description: Kir6 (KATP) channel opener
Alternative Names: BRL 34915

Chemical Name: trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile

Purity: ≥99%

Product Details
Citations (7)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Cromakalim is a prototypical Kir6 (KATP) channel opener. Relaxes rabbit isolated portal vein with an IC50 value of 21 nM. Potent, orally active and hypotensive in vivo.

Active Enantiomer also available.

Technical Data

M.Wt:
286.33
Formula:
C16H18N2O3
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
94470-67-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license
Other Product-Specific Information:

Product Datasheets

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Citations for Cromakalim

The citations listed below are publications that use Tocris products. Selected citations for Cromakalim include:

7 Citations: Showing 1 - 7

  1. Altered potassium ATP channel signaling in mesenteric arteries of old high salt-fed rats.
    Authors: Whidden Et al.
    J Exerc Nutrition Biochem  2016;20:58
  2. Antidiarrhoeal, antisecretory and antispasmodic activities of Matricaria chamomilla are mediated predominantly through K(+)-channels activation.
    Authors: Mehmood Et al.
    PLoS One  2015;15:75
  3. Acute SimV. inhibits K ATP channels of porcine coronary artery myocytes.
    Authors: Seto Et al.
    Am J Physiol Heart Circ Physiol  2013;8:e66404
  4. The sGC activator BAY 60-2770 has potent erectile activity in the rat.
    Authors: Lasker Et al.
    Am J Physiol Heart Circ Physiol  2013;304:H1670
  5. Involvement of the NO-cGMP-K(ATP) channel pathway in the mesenteric lymphatic pump dysfunction observed in the guinea pig model of TNBS-induced ileitis.
    Authors: Mathias and Weid
    Am J Physiol Gastrointest Liver Physiol  2013;304:G623
  6. Impaired vascular responses of Ins-resistant rats after mild subarachnoid hemorrhage.
    Authors: Institóris Et al.
    PLoS One  2011;300:H2080
  7. Alterations in KATP and KCa channel function in cerebral arteries of Ins-resistant rats.
    Authors: Erdos Et al.
    Am J Physiol Heart Circ Physiol  2002;283:H2472

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