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Cyclo(-RGDfK)

Catalog #: 8917 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8917/5
Cyclo(-RGDfK)
1 Image
Description: Potent integrin inhibitor (αvβ3/αvβ6); also improves stem cell attachment in 3D cell culture scaffolds

Purity: ≥95%

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Biological Activity

Cyclo(-RGDfK) is a cyclic peptide, potent integrin inhibitor (IC50 values are 2.3 and 55 nM for αvβ3 and αvβ6, respectively). Cyclo(-RGDfK) improves human pluripotent stem cell (hPSC) adhesion and proliferaton on 3D cell culture synthetic surfaces. Can also be used to target fluorophores and cargo to cancer cells as αvβ3 integrin is upregulated on cancer cells.

Technical Data

M.Wt:
603.68
Formula:
C27H41N9O7
Sequence:
RGDFK

(Modifications: Lactam bridge: Arg-1 to Lys-5, Phe-4:D-Phe)

Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
161552-03-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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