CyPPA

Tocris Bioscience | Catalog # 2953

KCa2.2 and KCa2.3 (SK) channel activator
Tocris Bioscience

Key Product Details

Description

KCa2.2 and KCa2.3 (SK) channel activator
View all Ca2+-Activated Potassium Channel Activators »

Product Description

CyPPA is an activator of small conductance Ca2+-activated K+ channels that displays selectivity for KCa2.2 (SK2) and KCa2.3 (SK3) channels (EC50 values are 5.6 and 14 μM for KCa2.3 and KCa2.2 respectively). Displays no activity at KCa2.1 (SK1) and KCa3.1 (IK) channels.

Product Specifications for CyPPA

Molecular Weight

285.39

Formula

C16H23N5

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

N-Cyclohexyl-N-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-4-pyrimidinamine

CAS Number

73029-73-9

PubChem ID

909822

InChI Key

USEMRPYUFJNFQN-UHFFFAOYSA-N

SMILES

CC1=NC(N2N=C(C)C=C2C)=NC(NC3CCCCC3)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 22 publications citing the usage of this product.

Product Documents for CyPPA

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CyPPA

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for CyPPA (1)

5 out of 5
1 Customer Rating
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used CyPPA?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 1 的 1 review Showing All
Filter By:
Clear Filters X
  • CyPPA was used to study small conductance SK channel activation
    Name: Eleanor Baxter
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/23/2018
    CyPPA was used to study small conductance SK channel activation along with other activators as a measure of comparison. The compound shows reasonable calcium activated potassium channel opening.
    CyPPA 2953

There are no reviews that match your criteria.

Showing  1 - 1 的 1 review Showing All