dBRD9

Tocris Bioscience | Catalog # 6606

Potent and selective BRD9 Degrader (PROTAC®)
Tocris Bioscience

Key Product Details

Description

Potent and selective BRD9 Degrader (PROTAC®)
View all Active Degraders »

Product Description

dBRD9 is a potent and selective Degrader (PROTAC®) of BRD9 (IC50 = 56.6 nM in MOLM-13 cells). dBRD9 is composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide (Cat. No. 6302). Does not degrade BRD4 or BRD7 at concentrations up to 5 μM. Displays antiproliferative effects in human AML cell lines. BRD9 antibody validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # NBP3-14730.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Dana-Farber Cancer Institute.

Product Specifications for dBRD9

Molecular Weight

856.75

Formula

C40H45N7O10.2HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-[[[4-(1,2-Dihydro-2-methyl-1-oxo-2,7-naphthyridin-4-yl)-2-6-dimethoxyphenyl]methyl]methylamino]-N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]acetamide dihydrochloride

CAS Number

2341840-98-8

PubChem ID

135397681

InChI Key

AIOCFZJGGGEWDK-UHFFFAOYSA-N

SMILES

COC1=CC(C2=CN(C(C3=CN=CC=C23)=O)C)=CC(OC)=C1CN(CC(NCCOCCOCCNC4=C5C(N(C(C5=CC=C4)=O)C6CCC(NC6=O)=O)=O)=O)C.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 17.14 20
DMSO 42.84 50

Preparing Stock Solutions for dBRD9

The following data is based on the product molecular weight 856.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 2.33 mL 11.67 mL 23.34 mL
2.5 mM 0.47 mL 2.33 mL 4.67 mL
5 mM 0.23 mL 1.17 mL 2.33 mL
25 mM 0.05 mL 0.23 mL 0.47 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 12 publications citing the usage of this product.

Product Documents for dBRD9

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for dBRD9

For research use only

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