(±)-U-50488 hydrochloride

Tocris Bioscience | Catalog # 0495

Selective κ agonist
Tocris Bioscience

Key Product Details

Description

Selective κ agonist
View all Kappa Opioid Receptor Agonists »

Product Description

(±)-U-50488 hydrochloride is a selective κ-opioid agonist. At higher concentrations blocks Na+ channels.

(-)-enantiomer and (+)-enantiomer also available.

Product Specifications for (±)-U-50488 hydrochloride

Molecular Weight

405.79

Formula

C19H26Cl2N2O.HCl

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

trans-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride

CAS Number

67197-96-0

PubChem ID

90479733

InChI Key

SKWPJQQGGZWRSK-PXOXCKTNSA-N

SMILES

O=C(CC3=CC(Cl)=C(Cl)C=C3)N([C@H]1[C@H](N2CCCC2)CCCC1)C.O=C(CC6=CC(Cl)=C(Cl)C=C6)N([C@@H]4[C@@H](N5CCCC5)CCCC4)C.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 10.14 25

Preparing Stock Solutions for (±)-U-50488 hydrochloride

The following data is based on the product molecular weight 405.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 9.86 mL 49.29 mL 98.57 mL
1.25 mM 1.97 mL 9.86 mL 19.71 mL
2.5 mM 0.99 mL 4.93 mL 9.86 mL
12.5 mM 0.20 mL 0.99 mL 1.97 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 21 publications citing the usage of this product.

Product Documents for (±)-U-50488 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (±)-U-50488 hydrochloride

For research use only

Citations for (±)-U-50488 hydrochloride

Customer Reviews for (±)-U-50488 hydrochloride (4)

5 out of 5
4 Customer Ratings
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used (±)-U-50488 hydrochloride?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 4 的 4 reviews Showing All
Filter By:
Clear Filters X
  • Beta arrestin recruitment
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 06/15/2021
    Dose response curve of beta arrestin recruitment (Presto_Tango assay)
    (±)-U-50488 hydrochloride 0495
  • JNK-dependent rescue of LTPGABA by acute norBNI
    Name: Anonymous
    Species: Rat
    Assay Type: In Vivo
    Cell Line/Tissue: brain
    Verified Customer | Posted 03/18/2020
    U50488 (5 mg/kg) injection
    (±)-U-50488 hydrochloride 0495
  • Great product
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: CHO
    Verified Customer | Posted 03/05/2020
    Successfully induced ERK1/2 phosphorylation in CHO cells expressing KOR.
    (±)-U-50488 hydrochloride 0495
  • Behavioral effects of kappa agonists
    Name: Matthew Banks
    Species: Rat
    Assay Type: In Vivo
    Verified Customer | Posted 01/05/2018
    soluble in water up to 5.6 mg/mL
    To evaluate the behavioral effects of unbiased and biased kappa agonists in animals
    (±)-U-50488 hydrochloride 0495

There are no reviews that match your criteria.

Showing  1 - 4 的 4 reviews Showing All