(-)-U-50488 hydrochloride

Tocris Bioscience | Catalog # 0496

Selective κ agonist; more active enantiomer of (±)-U-50488 (Cat. No. 0495)
Tocris Bioscience

Key Product Details

Description

Selective κ agonist; more active enantiomer of (±)-U-50488 (Cat. No. 0495)
View all Kappa Opioid Receptor Agonists »

Product Description

(-)-U-50488 hydrochloride is a more active enantiomer of (±)-U-50488.

Racemate and (+)-enantiomer also available.

Product Specifications for (-)-U-50488 hydrochloride

Molecular Weight

405.79

Formula

C19H26Cl2N2O.HCl

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

trans-(-)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride

CAS Number

114528-79-9

PubChem ID

9931141

InChI Key

KGMMGVIYOHGOKQ-APTPAJQOSA-N

SMILES

O=C(CC3=CC(Cl)=C(Cl)C=C3)N([C@@H]1[C@@H](N2CCCC2)CCCC1)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 8.12 20
DMSO 40.58 100

Preparing Stock Solutions for (-)-U-50488 hydrochloride

The following data is based on the product molecular weight 405.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.46 mL 12.32 mL 24.64 mL
5 mM 0.49 mL 2.46 mL 4.93 mL
10 mM 0.25 mL 1.23 mL 2.46 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 21 publications citing the usage of this product.

Product Documents for (-)-U-50488 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (-)-U-50488 hydrochloride

For research use only

Citations for (-)-U-50488 hydrochloride

Customer Reviews for (-)-U-50488 hydrochloride (3)

5 out of 5
3 Customer Ratings
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used (-)-U-50488 hydrochloride?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 3 的 3 reviews Showing All
Filter By:
Clear Filters X
  • Presto-Tango
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 06/15/2021
    Dose response curve of beta arrestin recruitment
    (-)-U-50488 hydrochloride 0496
  • Works very well
    Name: Luca Zangrandi
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: CHO
    Verified Customer | Posted 03/05/2020
    Agonist-induced ERK phosphorylation in CHO cells.
    (-)-U-50488 hydrochloride 0496
  • Behavior studies
    Name: Anonymous
    Assay Type: In Vivo
    Verified Customer | Posted 10/30/2017
    We have used this product numerous times in animal behavior studies and with consistent results.

There are no reviews that match your criteria.

Showing  1 - 3 的 3 reviews Showing All