DMG-PEG 2000

Name: DMG-PEG 2000
Brand: Tocris Bioscience
SKU: 7944
Price: 121 USD
Availability: InStock

Tocris Bioscience | Catalog # 7944

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Product Documents

PEGylated myristoyl diglyceride; commonly used in the formation of lipid nanoparticles (LNPs)

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

PEGylated myristoyl diglyceride; commonly used in the formation of lipid nanoparticles (LNPs)

View all Lipid Nanoparticles »

Product Description

DMG-PEG 2000 is a PEGylated myristoyl diglyceride consisting of one unbranched PEG 2000 chain and two saturated fatty acid chains (C14:0) covalently attached to a glycerol. DMG-PEG 2000 is commonly used in the formation of lipid nanoparticles (LNPs) and liposomes to prevent serum protein adsorption, nanoparticle aggregation and increase in vivo circulation time. DMG-PEG 2000 is a component of LNPs which can be used for delivery of RNA-based vaccines or mRNA therapeutics.

For more information on how to prepare MC3 lipid nanoparticles for RNA delivery, please see our protocol.

For a fully formulate LNP containing DLin-MC3-DMA and a luciferase mRNA reporter, see MC3 LNP Luciferase (Cat. No. 8889).

Product Specifications for DMG-PEG 2000

Formula

(C₂H₄O)_nC₃₂H₆₂O₅

Storage

Store at -20°C

Purity

≥90% (HPLC)

Chemical Name

1,2-Dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000

CAS Number

160743-62-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 10mg/ml in chloroform and to 10mg/ml in Ethanol

Calculators

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Background References

References are publications that support the biological activity of the product.

Zhang Functionalized lipid-like nanoparticles for in vivo mRNA delivery and base editing. Sci.Adv. 2020 PMID: 32937374
Cheng Dendrimer-based lipid nanoparticles deliver therapeutic FAH mRNA to normalize liver function and extend survival in a mouse model of hepatorenal tyrosinemia type I. Adv.Mater. 2018 PMID: 30368954

Product Documents for DMG-PEG 2000

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for DMG-PEG 2000

For research use only

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