DSPC

Key Product Details

Product Description

DSPC is a phosphatidylcholine, a type of neutral phospholipid with two saturated long-chains (18:0). Commonly used in the generation of micelles, liposomes, lipid nanoparticles (LNPs) and other types of artificial membranes. DSPC is used in formulation of LNPs for nonviral drug delivery systems.

For more information on how to prepare MC3 lipid nanoparticles for RNA delivery, please see our protocol.

For a fully formulate LNP containing DLin-MC3-DMA and a luciferase mRNA reporter, see MC3 LNP Luciferase (Cat. No. 8889).

Product Specifications for DSPC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for DSPC

The following data is based on the product molecular weight 790.15.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.27 mL	6.33 mL	12.66 mL
5 mM	0.25 mL	1.27 mL	2.53 mL
10 mM	0.13 mL	0.63 mL	1.27 mL
50 mM	0.03 mL	0.13 mL	0.25 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

• Zhang Liver-targeted siRNA lipid nanoparticles treat hepatic cirrhosis by dual antifibrotic and anti-inflammatory activities. ACS Nano 2020 PMID: 32378877
• Lou Delivery of self-amplifying mRNA vaccines by cationic lipid nanoparticles: The impact of cationic lipid selection. J.Control Release 2020 PMID: 32619745

Product Documents for DSPC