ELA-11 (human)

Name: ELA-11 (human)
Brand: Tocris Bioscience
SKU: 6698

Tocris Bioscience | Catalog # 6698

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High affinity apelin agonist

Discontinued Product

6698 has been discontinued. View all Apelin Receptor Agonists products.

Technical Data
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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

High affinity apelin agonist

View all Apelin Receptor Agonists »

Product Description

High affinity apelin receptor agonist (K_i = 14 nM). Bioactive fragment of ELA-32 (Cat. No. 6291). Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro.

Product Specifications for ELA-11 (human)

Molecular Weight

1283.57

Formula

C₅₈H₉₀N₁₆O₁₃S₂

Storage

Store at -20°C

CAS Number

1784687-32-6

PubChem ID

127043376

InChI Key

XXKPNJFJXZBRMX-HDKAIKTRSA-N

SMILES

[H]N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

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Background References

References are publications that support the biological activity of the product.

Murza Discovery and structure-activity relationship of a bioactive fragment of ELABELA that modulates vascular and cardiac functions. J.Med.Chem. 2016 PMID: 26986036
Yang Elabela/Toddler is an endogenous agonist of the apelin APJ receptor in the adult cardiovascular system, and exogenous administration of the peptide compensates for the downregulation of its expression in pulmonary arterial hypertension. Circulation 2017 PMID: 28137936

Product Documents for ELA-11 (human)

Certificate of Analysis

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Product Specific Notices for ELA-11 (human)

For research use only

Related Research Areas

Chemokines and Receptors

Infectious Diseases

Obesity

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