ELA-11 (human)
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Description: High affinity apelin agonist
Biological Activity
High affinity apelin receptor agonist (Ki = 14 nM). Bioactive fragment of ELA-32 (Cat. No. 6291). Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro.Technical Data
M.Wt:
1283.57
Formula:
C58H90N16O13S2
Sequence:
CMPLHSRVPFP
Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
1784687-32-6
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Discovery and structure-activity relationship of a bioactive fragment of ELABELA that modulates vascular and cardiac functions.
Murza et al.
J.Med.Chem., 2016;59:2962 -
Elabela/Toddler is an endogenous agonist of the apelin APJ receptor in the adult cardiovascular system, and exogenous administration of the peptide compensates for the downregulation of its expression in pulmonary arterial hypertension.
Yang et al.
Circulation, 2017;135:1160
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