Chemokines and Receptors

Chemokines are a large superfamily of mostly small, secreted chemotactic cytokines that function in leukocyte trafficking, recruitment and activation. They also play a critical role in many normal and pathophysiological processes such as allergic responses, infectious and autoimmune diseases, angiogenesis, inflammation, tumor growth and metastasis, and hematopoietic development. Chemokines are divided into subfamilies based on conserved amino acid (aa) sequence motifs. Most family members have at least four conserved cysteine residues that form two intramolecular disulfide bonds. The subfamilies are defined by the position of the first two cysteine residues.

• Chemokine Superfamily Pathway
• Other Chemokine-related Ligands and Receptors
• Chemokine Receptor Intracellular Signaling
• Chemokines and Receptors in Allergy and Asthma
• Chemokines and Receptors in Tfh Cell Differentiation and Function

Related Information

• Mini-review: Chemokines I
• Chemokine Nomenclature
• Mini-review: Chemokines III
• Chemokines Induce Moesin Interaction with ICAM-3
• Glomerulonephritis: Beyond Inflammation
• Chemokine Receptors and Multiple Sclerosis Pathogenesis
• Chemokines & Anti-tumor Immune Responses
• Mini-review: Multiple Sclerosis: Immune Cell Access to the Central Nervous System
• Chemokines & Pregnancy
• Recent Citations: R&D Systems Products for Chemokine-related Cancer Research
• Human Chemokine Antibody Array
• Interactive Pathway: Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
• Flow Cytometry Antibodies for Chemokine Receptor Research
• Chemokines and Receptors in Angiogenesis
• B Cell Chemotaxis, Migration, and Adhesion