Entecavir

Key Product Details

Product Description

Entecavir is a potent and selective hepatitis B virus reverse transcriptase inhibitor (EC₅₀ = 3 nM); guanine analog. Inhibits hepatitis B virus replication in HepG2.2.15 cells. Displays selectively over HCMV, HSV-1, VZV, HIV and influenza (EC₅₀ values are 15, 32, 30-60, >10 and >80 μM respectively). Orally bioavailable.

Product Specifications for Entecavir

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Entecavir

The following data is based on the product molecular weight 277.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.61 mL	18.03 mL	36.06 mL
5 mM	0.72 mL	3.61 mL	7.21 mL
10 mM	0.36 mL	1.80 mL	3.61 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Bisacchi BMS-200475, a novel carbocyclic 2'-deoxyguanosine analog with potent and selective anti-hepatitis B virus activity in vitro Bioorganic & Medicinal Chemistry Letters
• Innaimo Identification of BMS-200475 as a potent and selective inhibitor of hepatitis B virus. Antimicrob. Agents Chemother. 1997 PMID: 9210663

Product Documents for Entecavir