Exemestane

Key Product Details

Product Description

Exemestane is an irreversible steroidal aromatase inhibitor (IC₅₀ = 20 nM). Destabilizes aromatase and lowers estrogen levels; orally active.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for Exemestane

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Exemestane

The following data is based on the product molecular weight 296.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.37 mL	16.87 mL	33.74 mL
5 mM	0.67 mL	3.37 mL	6.75 mL
10 mM	0.34 mL	1.69 mL	3.37 mL
50 mM	0.07 mL	0.34 mL	0.67 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

• di Salle Exemestane (FCE 24304), a new steroidal aromatase inhibitor. J.Steroid Biochem.Mol.Biol. 1992 PMID: 1525055
• Wang and Chen Aromatase destabilizer: novel action of exemestane, a Food and Drug Administration-approved aromatase inhibitor. Cancer Res. 2006 PMID: 17079446
• Miller Aromatase inhibitors: are there differences between steroidal and nonsteroidal aromatase inhibitors and do they matter? Oncologist 2008 PMID: 18695261
• Goss The steroidal aromatase inhibitor exeme. prevents bone loss in ovariectomized rats. Bone 2004 PMID: 15003786

Product Documents for Exemestane