FC 131
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Description: CXCR4 antagonist
Biological Activity
CXCR4 antagonist (IC50 = 126 nM). Displays anti-HIV activity in assays using NL4-3 and IIIB strains (EC50 = 21 nM for both strains).Technical Data
M.Wt:
729.84
Formula:
C36H47N11O6
Sequence:
XGYRR (Modifications: Cyclic peptide, X = 2-Nal, Tyr-3 = D-Tyr]
Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
606968-52-9
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131
Tamamura et al.
J.Med.Chem., 2005;48:380 -
Potent CXCR4 antagonists containing amidine type peptide bond isosteres.
Inokuchi et al.
ACS Med.Chem.Lett., 2011;2:477
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