Key Product Details

Species Reactivity

Human

Applications

Western Blot, ELISA

Label

HRP

Antibody Source

Polyclonal Sheep IgG
View all Fetal Hemoglobin Primary Antibodies »

Product Specifications

Immunogen

Purified human hemoglobin F of fetal cord blood cell origin.

Specificity

By immunoelectrophoresis and ELISA this antibody reacts specifically with human hemoglobin F. No antibody was detected against hemoglobin A1, A2, S or human serum proteins.

Clonality

Polyclonal

Host

Sheep

Isotype

IgG

Applications for Fetal Hemoglobin Antibody [HRP]

Application
Recommended Usage

ELISA

1:10000 - 1:100000

Western Blot

1:1000 - 1:30000
Application Notes
This antibody can be used as the detection antibody in sandwich ELISA with NB110-41084 as the capture antibody.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS containing 0.2% BSA

Preservative

0.05% Pro-Clean 400

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Fetal Hemoglobin

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.

Alternate Names

abnormal hemoglobin, A-gamma globin, gamma A hemoglobin, gamma globin, gamma-1-globin, gamma-2-globin, gamma-globin chain, G-gamma globin Paulinia, Hb F Agamma, hb F Ggamma, HBGA, HBGR, HBG-T1, HBG-T2, Hemoglobin gamma-1 chain, hemoglobin gamma-2 chain, Hemoglobin gamma-A chain, hemoglobin gamma-G chain, hemoglobin subunit gamma-1, hemoglobin subunit gamma-2, hemoglobin, gamma A, hemoglobin, gamma, regulator of, HSGGL1, methemoglobin, PRO2979

Gene Symbol

HBG1

Additional Fetal Hemoglobin Products

Product Documents for Fetal Hemoglobin Antibody [HRP]

Certificate of Analysis

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Product Specific Notices for Fetal Hemoglobin Antibody [HRP]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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