Fluticasone propionate

Tocris Bioscience | Catalog # 2007

Selective high affinity glucocorticoid receptor agonist
Tocris Bioscience

Key Product Details

Description

Selective high affinity glucocorticoid receptor agonist
View all Glucocorticoid Receptor Agonists »

Product Description

Fluticasone propionate is a high affinity, selective glucocorticoid receptor agonist (Kd = 0.5 nM). Potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC50 = 3.7 nM) in vitro. Inhibits mast cell accumulation in nasal mucosa following topical administration. Lipophilic anti-inflammatory agent with low oral bioavailability. Also potentiates KV1 channels (EC50 = 37 nM).

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Product Specifications for Fluticasone propionate

Molecular Weight

500.57

Formula

C25H31F3O5S

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

(6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid fluoromethyl ester

CAS Number

80474-14-2

PubChem ID

444036

InChI Key

WMWTYOKRWGGJOA-CENSZEJFSA-N

SMILES

O=C1C=C[C@@]2(C)C([C@@H](F)C[C@]3([H])[C@@](F)2[C@@H](O)C[C@@]4(C)[C@]([H])3C[C@@H](C)[C@](C(SCF)=O)4OC(CC)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.03 50

Preparing Stock Solutions for Fluticasone propionate

The following data is based on the product molecular weight 500.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.00 mL 19.98 mL 39.95 mL
2.5 mM 0.80 mL 4.00 mL 7.99 mL
5 mM 0.40 mL 2.00 mL 4.00 mL
25 mM 0.08 mL 0.40 mL 0.80 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 441 publications citing the usage of this product.

Product Documents for Fluticasone propionate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Fluticasone propionate

For research use only

⚠ WARNING: This product can expose you to chemicals including Fluticasone propionate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Fluticasone propionate

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