GA3-AM
Chemical Name: (1S,2S,4aR,4bR,7S,9aS,10S,10aR)-1,2,4b,5,6,7,8,9,10,10a-Decahydro-2,7-dihydroxy-1-methyl-8-methylene-13-oxo-4a,1-(epoxymethano)-7,9a-methanobenz[a]azulene-10-acetic acid (acetyloxy)methyl ester
Purity: ≥90%
Biological Activity
GA3-AM is a Gibberellin-analog (GA3) chemical dimerizer; induces rapid dimerization of GAIs and GID1. GA3-AM crosses the plasma membrane, is cleaved by cytosolic esterase releasing GA3, which then binds GID1- this complex then in turn forms a complex with GAI; this system works on a timescale of seconds (EC50 = 310 nM). GA3 and rapamycin (Cat. No. 1292) chemically inducible dimerization systems are orthogonal. Cell permeable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Rapid and orthogonal logic gating with a gibberellin-induced dimerization system
Miyamoto et al.
Nat.Chem.Biol., 2012;8:465 -
Rapidly reversible manipulation of molecular activities using dual chemical dimerizers
Lin et al.
Angew.Chem.Int.Ed.Engl., 2013;52:6450
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Citations for GA3-AM
The citations listed below are publications that use Tocris products. Selected citations for GA3-AM include:
2 Citations: Showing 1 - 2
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Passage number affects differentiation of sensory neurons from human induced pluripotent stem cells.
Authors: Xi Et al.
Sci Rep 2022;12:15869
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5-HT2A receptor activation enhances NMDA receptor-mediated glutamate responses through Src kinase in the dendrites of rat jaw-closing motoneurons.
Authors: Yong Chul Et al.
J Physiol 2019;597:2565-2589
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