Key Product Details

Species Reactivity

Human, Mouse

Applications

Western Blot, ELISA

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all GITR Ligand/TNFSF18 Primary Antibodies »

Product Specifications

Immunogen

Antibody was raised against purified recombinant human GITR ligand.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Novus Biologicals Rabbit GITR Ligand/TNFSF18 Antibody - BSA Free (NBP1-77240) is a polyclonal antibody validated for use in WB, ELISA and ICC/IF. All Novus Biologicals antibodies are covered by our 100% guarantee.

Scientific Data Images for GITR Ligand/TNFSF18 Antibody - BSA Free

Western Blot: GITR Ligand/TNFSF18 AntibodyBSA Free [NBP1-77240]

Western Blot: GITR Ligand/TNFSF18 AntibodyBSA Free [NBP1-77240]

Western Blot: GITR Ligand/TNFSF18 Antibody [NBP1-77240] - Analysis of (A) 5 ng, (B) 25 ng, and (C) 50 ng of purified recombinant GITRL with ITRL antibody at 1 ug/mL.

Immunocytochemistry/Immunofluorescence: GITR Ligand/TNFSF18 Antibody [NBP1-77240] -

Immunocytochemistry/Immunofluorescence: GITR Ligand/TNFSF18 Antibody [NBP1-77240] - GITRL in THP-1 cells with GITR Ligand antibody at 10 ug/mL.

Applications for GITR Ligand/TNFSF18 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Western Blot

1 ug/ml

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GITR Ligand/TNFSF18

The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-kappaB and various mitogen-activated protein kinases. The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions. Its ligand GITRL is expressed in endothelial and antigen-presenting cells and can activate NF-kappaB, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR. Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-kappaB activation, suggesting that the GITRL-GITR pathway involves both NIK and TRAF2.

Long Name

Glucocorticoid Induced TNF Receptor Family Related Gene Ligand

Alternate Names

AITRL, GITRL, TNFSF18

Gene Symbol

TNFSF18

UniProt

Q9UNG2

Additional GITR Ligand/TNFSF18 Products

Product Documents for GITR Ligand/TNFSF18 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for GITR Ligand/TNFSF18 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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