GW 9508

Key Product Details

Product Description

GW 9508 is a potent and selective agonist for the free fatty acid receptor FFA1 (GPR40) (pEC₅₀ values are 7.32, < 4.3 and < 4.3 for FFA1, FFA2 and FFA3 receptors respectively). Inactive against a range of other GPCRs, kinases, proteases, integrins and PPARs. Potentiates glucose-stimulated insulin secretion in MIN6 cells (pEC₅₀ = 6.14).

Licensing Information

Sold with the permission of GlaxoSmithKline

Product Specifications for GW 9508

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GW 9508

The following data is based on the product molecular weight 347.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.88 mL	14.39 mL	28.78 mL
5 mM	0.58 mL	2.88 mL	5.76 mL
10 mM	0.29 mL	1.44 mL	2.88 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 32 publications citing the usage of this product.

• Briscoe Pharmacological regulation of Ins secretion in MIN6 cells through fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br.J.Pharmacol. 2006 PMID: 16702987
• Zhao and Chen Activation of ATP-sensitive potassium channels in rat pancreatic β-cells by linoleic acid through both intracellular metabolites and membrane receptor signalling pathway. J.Endocrinol. 2008 PMID: 18550787
• Garrido Synthesis and activity of small molecule GPR40 agonists. Bioorg.Med.Chem.Lett. 2006 PMID: 16439116

Product Documents for GW 9508