GW 9662

Tocris Bioscience | Catalog # 1508

Selective covalent PPARγ antagonist
Tocris Bioscience

Key Product Details

Description

Selective covalent PPARγ antagonist
View all PPAR gamma Receptor Antagonists »

Product Description

GW 9662 is a selective irreversible PPARγ antagonist (IC50 values are 3.3, 32 and 2000 nM for PPARγ, PPARα and PPARδ respectively). Blocks the inhibition of osteoclast formation induced by IL-4 in the low micromolar range (1-2 μM), therefore is more potent than BADGE. Anticancer, inhibits growth of human mammary tumor cell lines.

Product Specifications for GW 9662

Molecular Weight

276.68

Formula

C13H9N2O3Cl

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

2-Chloro-5-nitro-N-phenylbenzamide

CAS Number

22978-25-2

PubChem ID

644213

InChI Key

DNTSIBUQMRRYIU-UHFFFAOYSA-N

SMILES

[O-][N+](=O)C1=CC(C(=O)NC2=CC=CC=C2)=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.67 100
Ethanol 6.92 25 with gentle warming

Preparing Stock Solutions for GW 9662

The following data is based on the product molecular weight 276.68.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.61 mL 18.07 mL 36.14 mL
5 mM 0.72 mL 3.61 mL 7.23 mL
10 mM 0.36 mL 1.81 mL 3.61 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

Calculators

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Product Documents for GW 9662

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GW 9662

For research use only

Customer Reviews for GW 9662 (3)

4.3 out of 5
3 Customer Ratings
5 Stars
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4 Stars
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3 Stars
33%
2 Stars
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1 Stars
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  • Great GW 9662
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Endothelial cell
    Verified Customer | Posted 12/05/2021
    GW 9662 at 2microM was used to test its effect on EC sprouting.
    GW 9662 1508
  • PPARy in m1 m2 macrophages
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: macrophage
    Verified Customer | Posted 09/24/2019
    Used this produce in mouse macrophages to inhibit ppar gamma at 1um. worked very well
  • GW 9662 partially inhibits 15d-PGJ2-mediated pp42/44 activation.
    Name: Chintan Koyani
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: HL-1 cardiomyocytes
    Verified Customer | Posted 12/10/2018
    HL-1 cardiomyocytes were incubated with GW 9662 (2 µM) for 30 min prior to addition of 15 µM 15d-PGJ2 for 30 min. Preincubation of cells with GW 9662 partially abolished activation of p42/44 MAPK, while Tesaglitazar and T 0070907 inhibited the activation completely.
    GW 9662 1508

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