HC 067047

Tocris Bioscience | Catalog # 4100

Potent and selective TRPV4 antagonist
Tocris Bioscience

Key Product Details

Description

Potent and selective TRPV4 antagonist
View all TRPV Antagonists »

Product Description

HC 067047 is a potent and selective TRPV4 antagonist. Reversibly inhibits currents through mouse, human and rat TRPV4 orthologs (IC50 values are 17, 48 and 133 nM respectively). Also inhibits the endogenous TRPV4-mediated response to 4α-PDH (IC50 = 22 nM). Selective for TRPV4 over TRPV1, TRPV2, TRPV3 and TRPM8 channels.

Product Specifications for HC 067047

Molecular Weight

471.51

Formula

C26H28F3N3O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide

CAS Number

883031-03-6

PubChem ID

2742550

InChI Key

NCZYSQOTAYFTNM-UHFFFAOYSA-N

SMILES

CC1=C(C(NC4=CC(C(F)(F)F)=CC=C4)=O)C=C(C3=CC=CC=C3)N1CCCN2CCOCC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 47.15 100
Ethanol 11.79 25

Preparing Stock Solutions for HC 067047

The following data is based on the product molecular weight 471.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.12 mL 10.60 mL 21.21 mL
5 mM 0.42 mL 2.12 mL 4.24 mL
10 mM 0.21 mL 1.06 mL 2.12 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 98 publications citing the usage of this product.

  • Everaerts Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. Proc.Natl.Acad.Sci.

Product Documents for HC 067047

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for HC 067047

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for HC 067047 (2)

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  • HC067047 inhibit TRPV4 channels in pig pregromerular arteries
    Name: Jennifer Neves
    Species: pig
    Assay Type: In Vitro
    Cell Line/Tissue: preglomerular arteries
    Verified Customer | Posted 01/23/2018
    HC067047 (1µM) was used to demonstrate that TRPV4 channels contribute to pressure-induced membrane depolarization, intracellular [Ca2+] elevation, and constriction in neonatal pig renal preglomerular arteries.
    HC 067047 4100
  • HC067047 to inhibit TRPV4 currents
    Name: Jennifer Neves
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: mesenteric endothelial cells
    Verified Customer | Posted 01/23/2018
    HC067047 was used as a tool to demonstrate that eugenol activates TRPV4 currents in rat mesenteric artery endothelial cells using patch clamp electrophysiology.
    HC 067047 4100

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