HDAC4 CHDI Degrader 11

Tocris Bioscience | Catalog # 7882

Potent and selective HDAC4 Degrader (PROTAC®)
Tocris Bioscience

Key Product Details

Description

Potent and selective HDAC4 Degrader (PROTAC®)
View all Active Degraders »

Product Description

HDAC4 CHDI Degrader 11 is a potent and selective HDAC4 Degrader (PROTAC®) (DC50 values are 4 and 6 nM in Jurkat E6-1 and Jurkat cells respectively). Comprises the class IIa HDAC inhibitor trifluoromethyloxadiazole joined by a linker to a ligand for Von Hippel-Lindau (VHL) protein. In a mouse cell model of Huntington's disease, HDAC4 CHDI Degrader 11 potently degrades HDAC4 (DC50 = 1nM). Can be used with P-glycoprotein inhibitor Elacridar (Cat. No. 4646) for more effective degradation in neuroblastoma cell lines.

HDAC4 antibody validated for Simple Western™ (automated Western) instruments also available: Catalog # NBP2-22151.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for HDAC4 CHDI Degrader 11

Molecular Weight

1075.26

Formula

C52H73F3N8O11S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2S,4R)-1-((3R,26S)-26-(tert-Butyl)-3-methyl-1,24-dioxo-5-propyl-1-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)-10,13,16,19,22-pentaoxa-2,5,25-triazaheptacosan-27-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

CAS Number

3035189-46-6

InChI Key

KBDZFZJFGKYVBZ-KLSSUPLUSA-N

SMILES

O=C(NCC1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](NC(COCCOCCOCCOCCOCCCCN(C[C@H](NC(C4=CC=C(C=C4)C5=NOC(C(F)(F)F)=N5)=O)C)CCC)=O)C(C)(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 53.76 50

Preparing Stock Solutions for HDAC4 CHDI Degrader 11

The following data is based on the product molecular weight 1075.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 1.86 mL 9.30 mL 18.60 mL
2.5 mM 0.37 mL 1.86 mL 3.72 mL
5 mM 0.19 mL 0.93 mL 1.86 mL
25 mM 0.04 mL 0.19 mL 0.37 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for HDAC4 CHDI Degrader 11

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for HDAC4 CHDI Degrader 11

For research use only

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