HHP 9

Tocris Bioscience | Catalog # 7828

BET bromodomain Degrader (PROTAC®); also potent Hedgehog pathway inhibitor
Tocris Bioscience

Key Product Details

Description

BET bromodomain Degrader (PROTAC®); also potent Hedgehog pathway inhibitor
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Product Description

HHP 9 is a potent BET bromodomain Degrader (PROTAC®; DC50 values are 0.03 μM, 0.2 μM and 0.2 μM at BRD3, BRD2 and BRD4 respectively). BRD2, BRD3 and BRD4 are almost completely degraded by HHP 9 in vitro (after 27h incubation with 0.5 - 5 μM of HHP 9). Comprises a Hedgehog Pathway Inhibitor-1 (HPI-1, Cat. No. 3839) coupled to a CRBN ligand. BET bromodomain degradation through HPP-9 results in long-acting Hh pathway inhibition.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for HHP 9

Molecular Weight

900.99

Formula

C49H52N6O11

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-Methoxyethyl 4-(3-((1-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

CAS Number

3093738-79-2

InChI Key

RJNFQVDPIFXYAO-UHFFFAOYSA-N

SMILES

CC1=C(C(OCCOC)=O)C(C2=CC(OCC3=CN(CCCCCCOC4=CC=CC(C(N5C6CCC(NC6=O)=O)=O)=C4C5=O)N=N3)=CC=C2)C7=C(N1)CC(C8=C(OC)C=CC=C8)CC7=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 90.1 100

Preparing Stock Solutions for HHP 9

The following data is based on the product molecular weight 900.99.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.11 mL 5.55 mL 11.10 mL
5 mM 0.22 mL 1.11 mL 2.22 mL
10 mM 0.11 mL 0.55 mL 1.11 mL
50 mM 0.02 mL 0.11 mL 0.22 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for HHP 9

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for HHP 9

For research use only

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