HIF-1 alpha/HIF1A Peptide Substrate, Biotin

R&D Systems | Catalog # S-340

R&D Systems
Discontinued Product
S-340 has been discontinued. View all HIF-1 alpha/HIF1A products.

Key Product Details

Source

Synthetic

Accession Number

Q16665

Conjugate

Biotin

Applications

Bioactivity
View all HIF-1 alpha/HIF1A Small Molecules and Peptides »

Product Specifications

Source

Chemically Synthesized

Purity

>98%, by HPLC.

Predicted Molecular Mass

5290.9 Da

Formulation, Preparation, and Storage

S-340
Formulation 100 μM in 10% (w/v) ammonium bicarbonate.
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Storeat -20°C or -80°C.  Avoid multiplefreeze/thaw cycles.

Background: HIF-1 alpha/HIF1A

This biotinylated peptide includes a sequence from human Hypoxia-Inducible Factor 1-alpha (HIF-1 alpha ) including a 4-hydroxyline proline residue corresponding to proline 564 in UniProt Q16665.  The peptide can be ubiquitinated by a VHL/Elongin B/Elongin C/CUL2/RBX complex (catalog number E3-655) in vitro using wild-type ubiquitin or lysine-less ubiquitin ("Ub-NOK").  A matched negative control peptide (catalog S-345) with an unmodified proline residue is available; depending on experimental conditions the negative control peptide is ubiquitinated at ≤ 5% of the level of the peptide containing 4-hydroxyproline.

Long Name

Hypoxia Inducible Factor 1 Subunit Alpha

Alternate Names

BHLHE78, HIF 1A, HIF-1a, HIF1 alpha, HIF1A, MOP1, PASD8

Entrez Gene IDs

3091 (Human); 15251 (Mouse); 29560 (Rat)

Gene Symbol

HIF1A

UniProt

Q16665

Additional HIF-1 alpha/HIF1A Products

Product Documents for HIF-1 alpha/HIF1A Peptide Substrate, Biotin

Certificate of Analysis

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Product Specific Notices for HIF-1 alpha/HIF1A Peptide Substrate, Biotin

For research use only

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