HPS3 Antibody

Novus Biologicals | Catalog # NB100-1445

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (100%), Mouse (100%), Porcine (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all HPS3 Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence PYLLYCSRKKPLT corresponding to C-Terminus according to NP_115759.2.

Localization

Cytoplasmic

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for HPS3 Antibody

Western Blot: HPS3 Antibody [NB100-1445]

Western Blot: HPS3 Antibody [NB100-1445]

Western Blot: HPS3 Antibody [NB100-1445] - (1ug/ml) staining of A431 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for HPS3 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:32000

Western Blot

1 - 3 ug/ml
Application Notes
WB: Approx. 110 kDa band observed in A431 lysate (calculated MW of 114 kDa band according to NP_115759).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: HPS3

HPS3 is involved in early stages of melanosome biogenesis and maturation. Defects in HPS3 are the cause of the cocoa (coa) mutant, and of Hermansky-Pudlak syndrome type 3 (HPS3). HPS3 is an autosomal recessive disorder, characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS.

Alternate Names

DKFZp686F0413, FLJ22704, Hermansky-Pudlak syndrome 3, Hermansky-Pudlak syndrome 3 protein, SUTAL

Entrez Gene IDs

84343 (Human)

Gene Symbol

HPS3

UniProt

NP_115759. (Human)

Additional HPS3 Products

Product Documents for HPS3 Antibody

Certificate of Analysis

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Product Specific Notices for HPS3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs

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