Human APBA3 Alexa Fluor® 750-conjugated Antibody

Catalog #: AF5689S Datasheet / COA / SDS

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AF5689S-100UG

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human APBA3 Alexa Fluor® 750-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human APBA3 in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross‑reactivity with recombinant human (rh) X11‑ alpha and rhX11-beta is observed.

Source

Polyclonal Sheep IgG

Purification

Antigen Affinity-purified

Immunogen

E. coli-derived recombinant human APBA3
Met1-Leu138
Accession # O96018

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 750 (Excitation= 749 nm, Emission= 775 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: APBA3

X11-gamma (Adaptor protein X11 gamma; also APBA3, Mint3 and X11L2) is a member of the X11 family of adaptor proteins. Unlike X11 alpha and -beta which are generally neuronal proteins, X11-gamma is widely expressed in all tissues. X11-gamma has many functions, including MT-MMP and Furin intracellular trafficking and APP binding. Human X11-gamma is 575 amino acids (aa) in length. It contains a poly-Ser segment (aa 165‑171), a PID region (aa 217‑381) that binds beta -amyloid precursor, and two PDZ domains (aa 393‑478 and 485‑560) that bind Arf GTPases. There is one potential splice variant that shows a 34 aa insertion after Ile505. Over aa 1‑138, human X11‑ gamma shares 62% aa identity with mouse X11‑ gamma.

Long Name

Amyloid Beta [A4] Precursor Protein-binding, Family A, Member 3

Entrez Gene IDs

9546 (Human); 57267 (Mouse); 83611 (Rat)

Alternate Names

Adapter protein X11gamma; amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2); amyloid beta (A4) precursor protein-binding, family A, member 3; APBA3; MGC:15815; MINT3; mint-3; Neuronal Munc18-1-interacting protein 3; Neuron-specific X11L2 protein; phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; X11L2; X11L2amyloid beta A4 precursor protein-binding family A member 3; X11-like 2 protein