Human CYP3A4 Alexa Fluor® 488-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: CYP3A4

CYP3A4 (cytochrome P450, subfamily 3A, polypeptide 4) belongs to the cytochrome P450 superfamily of monooxygenases that catalyze reactions involved in both drug metabolism and the synthesis of cholesterol, steroids, and other lipid components.  CYP3A4 is predominantly found in liver microsomes, but has also been detected in prostate, small and large intestine, bile duct, nasal mucosa, kidney and adrenal cortex.  It is an extremely important enzyme for drug metabolism; CYP3A4 catalyzes phase I oxidation reactions in an estimated 60% of all clinically used drugs, promoting in most cases their clearance by excretion.  CYP3A4 levels are induced by glucocorticoids and various xenobiotics, including drugs, pesticides and carcinogens.  Human CYP3A4 is a 50 kDa single-pass membrane protein, 503 amino acids in length.

Product Datasheets

Related Research Areas

• Hepatic Endoderm
• Hepatic Endoderm Cell Markers
• Oxidases and Oxygenases
• Steroid Hormone Receptors and Regulators
• Steroid Hormones and Bioactive Lipids