Human FGFR3 (IIIb) Alexa Fluor® 488-conjugated Antibody

Catalog #: FAB1474G Datasheet / COA / SDS

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FAB1474G-100UG

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Human FGFR3 (IIIb) Alexa Fluor® 488-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human FGF R3 (IIIb) in direct ELISAs. In direct ELISAs, approximately 25‑50% cross-reactivity with recombinant mouse FGF R3 (IIIb) is observed and 12% with recombinant human (rh) FGF R4 is observed and no cross-

Source

Monoclonal Mouse IgG1 Clone # 136315

Purification

Protein A or G purified

Immunogen

Pool of NS0-derived recombinant human FGFÂ R3 alpha (IIIb) and Sf21-derived FGF R3 alphaÂ (IIIc)

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 488 (Excitation= 488 nm, Emission= 515-545 nm)

Applications

Recommended Concentration

Sample

Neutralization

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: FGFR3

Fibroblast Growth Factor Receptor 3 (FGF R3) is a type I transmembrane tyrosine kinase receptor that binds FGF ligands along with heparin or heparin sulfateproteoglycans as cofactors. A segment of the membrane proximal Ig-like domain can be encoded by two different exons resulting in (IIIb) or (IIIc) isoforms. The IIIb or IIIc isoforms recognize FGF-1, -2, -4, -8b, -8e, -8f, -9,and -17b. FGF R3 plays a role in skeletal, brain, lung, intestine, kidney, and skin development.

Long Name

Fibroblast Growth Factor Receptor 3

Entrez Gene IDs

2261 (Human); 14184 (Mouse)

Alternate Names

CD333; CEK; EC 2.7.10; FGF R3; FGFR3; fibroblast growth factor receptor 3; HSFGFR3EX; JTK4; JTK4thanatophoric dwarfism