FGF Family

The Fibroblast Growth Factors (FGFs) constitute a large family of proteins involved in many aspects of development including cell proliferation, growth, and differentiation. They act on several cell types to regulate diverse physiologic functions including angiogenesis, cell growth, pattern formation, embryonic development, metabolic regulation, cell migration, neurotrophic effects, and tissue repair. FGF family activities are mediated by receptor tyrosine kinases and are facilitated by heparan sulfate. Family members have been implicated in several disorders of bone growth, as well as in tumor formation and progression.

FGF Ligands

• FGF acidic/FGF1
• FGF basic/FGF2/bFGF
• FGF-3
• FGF-4
• FGF-5
• FGF-6
• KGF/FGF-7
• FGF-8
• FGF-9
• FGF-10
• FGF-11
• FGF-12
• FGF-13
• FGF-15
• FGF-16
• FGF-17
• FGF-18
• FGF-19
• FGF-20
• FGF-21
• FGF-22
• FGF-23

FGF Receptors

• FGF Receptor Inhibitors
• FGFR1
• FGFR1 alpha
• FGFR1 beta
• FGFR1-4
• FGFR2
• FGFR2 alpha
• FGFR2 beta
• FGFR3
• FGFR4
• FGFR5/FGFRL1
• Golgi Glycoprotein 1/GLG1

FGF Regulators

• alpha 2-Macroglobulin
• alpha 2-Macroglobulin-like 1/A2ML1
• CNPY2
• FGF Receptor Inhibitors
• FGF-BP
• FGFBP2
• FGFBP3
• FLRT1
• FLRT2
• FLRT3
• FRS2
• Klotho
• Klotho beta
• LRIT3
• Pentraxin 3/TSG-14
• Shisa-4
• SPRY1
• SPRY2
• SPRY3

Related Information

• FGF-21: From Cloning to Clinic
• Klotho Proteins: Novel Cofactors for Endocrine FGFs
• Platelet Activation Granule Release
• BIObrief: Fibroblast Growth Factor Superfamily
• Receptor Tyrosine Kinases (RTKs)
• FGF Superfamily Schematic
• Extracellular Matrix and Related Molecules