Insulin Receptor (INSR, CD220) is a type I transmembrane glycoprotein in the Insulin/IGF Receptor family of receptor tyrosine kinases. The mature receptor contains an extracellular alpha subunit and an extracellular/transmembrane/cytoplasmic beta subunit. Alternative splicing generates A and B isoforms which may homodimerize or heterodimerize with the IGF-I receptor. All receptor combinations bind Insulin, IGF-I, or IGF-II, but with differing affinities. Insulin R signaling regulates glucose uptake and metabolism but also contributes to cell growth, differentiation and apoptosis. Mutations in INSR have been linked to severe insulin resistance (type A and Rabson-Mendenhall syndrome), type II diabetes mellitus, and leprechaunism (Donohue syndrome)
Human Insulin R/CD220 (NP_000199) VersaClone cDNA
R&D Systems | Catalog # RDC1239
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Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: Insulin R/CD220
Long Name
Insulin Receptor
Alternate Names
CD220, INSR, InsulinR
Gene Symbol
INSR
UniProt
Additional Insulin R/CD220 Products
Product Documents for Human Insulin R/CD220 (NP_000199) VersaClone cDNA
Product Specific Notices for Human Insulin R/CD220 (NP_000199) VersaClone cDNA
For research use only
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