Human iRHOM2/RHBDF2 Alexa Fluor® 647-conjugated Antibody

Catalog #: FAB10048R Datasheet / COA / SDS

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FAB10048R-100UG

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Human iRHOM2/RHBDF2 Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects huma iRHOM2/RHBDF2 in direct ELISAs and Western blots.

Source

Monoclonal Mouse IgG2a Clone # 996308

Purification

Protein A or G purified

Immunogen

Synthetic peptide containing human iRHOM2/RHBDF2
Accession # Q6PJF2

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: iRHOM2/RHBDF2

Human Inactive rhomboid protein 2 (RHBDF2 or IRHOM2) is a highly conserved seven-transmembrane Rhomboid protease-like protein which is inactive, it has no protease activity, but has been implicated in the secretion of several ligands of the epidermal growth factor receptor (EGFR), probably by regulating trafficking and stability of key protein membrane like ADAM17 and STING. The RHBDF2 protein plays an important role in the secretion of tumor necrosis factor alpha and has been implicated in familial esophageal cancer. Gain-of-function (GOF) mutations in the RHBDF2 gene constitutively activate EGFR signaling to cause tylosis with esophageal cancer syndrome.

Long Name

Rhomboid 5 Homolog 2

Entrez Gene IDs

79651 (Human); 217344 (Mouse); 303690 (Rat)

Alternate Names

FLJ22341; iRHOM2; RHBDF2; RHBDL5; RHBDL5rhomboid family member 2; RHBDL6; rhomboid 5 homolog 2 (Drosophila); Rhomboid 5 homolog 2; rhomboid veinlet-like 5; Rhomboid veinlet-like protein 5; Rhomboid veinlet-like protein 6; rhomboid, veinlet-like 6 (Drosophila); rhomboid, veinlet-like 6; rhomboid-like protein 6; TOCG