Human KLF6 Alexa Fluor® 647-conjugated Antibody

Catalog #: AF3499R Datasheet / COA / SDS

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AF3499R-100UG

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Human KLF6 Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human KLF6 in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody shows less than 5% cross‑reactivity with rhKLF4, rhKLF5 and rmKLF15.

Source

Polyclonal Sheep IgG

Purification

Antigen Affinity-purified

Immunogen

E. coli-derived recombinant human KLF6
Met1-Ser109
Accession # Q99612

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: KLF6

KLF6 is a ubiquitously expressed nuclear protein belonging to the Kruppel C2H2-type zinc finger transcription factor family. It is a 283 amino acid (aa) protein that contains an N-terminal acidic domain, a Ser/Thr-rich region and three zinc-finger motifs. The acidic region may interact with other transcription factors. The Ser-Thr-rich region likely serves as an activation domain, and the zinc-finger motifs bind DNA. One alternate splice form is known that shows a 55 aa substitution for the C‑terminal 57 amino acids. KLF6 is considered a tumor-suppressor gene. It also promotes iNOS and TGF-beta 1 expression. Human KLF6 shares 94%, 95% and 94% aa sequence identity with rat, mouse and canine KLF6, respectively.

Long Name

Kruppel-Like Factor 6

Entrez Gene IDs

1316 (Human); 23849 (Mouse); 58954 (Rat)

Alternate Names

BCD1; BCD1Zf9; B-cell-derived protein 1; COPEB; COPEBCBA1; core promoter element binding protein; Core promoter element-binding protein; CPBP; CPBPZF9; DKFZp686N0199; EC 2.1.1.43; EC 6.1.1.15; GBF; GC-rich binding factor; GC-rich sites-binding factor GBF; KLF6; Krueppel-like factor 6; Kruppel-like factor 6; Kruppel-like zinc finger protein Zf9; PAC1; Proto-oncogene BCD1; protooncogene B-cell derived 1; ST12; suppression of tumorigenicity 12 (prostate); Suppressor of tumorigenicity 12 protein; Transcription factor Zf9