Human/Mouse IRF6 Alexa Fluor® 750-conjugated Antibody

Catalog #: FAB6114S Datasheet / COA / SDS

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FAB6114S-100UG

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Human/Mouse IRF6 Alexa Fluor® 750-conjugated Antibody Summary

Species Reactivity

Human, Mouse

Specificity

Detects human and mouse IRF6 in Western blots.

Source

Monoclonal Mouse IgG2b Clone # 503404

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human IRF6
Ala176-Gln366
Accession # O14896

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 750 (Excitation= 749 nm, Emission= 775 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: IRF6

Interferon regulatory factor 6 (IRF6), is a transcription factor that controls the proliferation and differentiation of epidermal and epithelial cells. IRF6 interacts with maspin in normal mammary epithelial cells but is down‑regulated during tumor progression. IRF6 polymorphisms cause Van der Woude and popliteal pterygium syndromes of skin, limb, and craniofacial development that are characterized by cleft lip, cleft palate, or lip pits. IRF6 contains an N-terminal DNA binding domain that is homologous to that in other IRF proteins. Within aa 176‑366 of the C‑terminal domain, human IRF6 shares 98% aa sequence identity with mouse and rat IRF6.

Long Name

Interferon Regulatory Factor 8

Entrez Gene IDs

3664 (Human); 54139 (Mouse); 364081 (Rat)

Alternate Names

interferon regulatory factor 6; IRF6; IRF-6; LPS; OFC6; OFC6PPS; PIT; PPS; Van der Woude syndrome; VWS; VWS1