Human/Mouse Otoraplin/OTOR Alexa Fluor® 647-conjugated Antibody

Catalog #: AF3979R Datasheet / COA / SDS

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AF3979R-100UG

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Human/Mouse Otoraplin/OTOR Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human, Mouse

Specificity

Detects human and mouse Otoraplin/OTOR in direct ELISAs and Western blots.

Source

Polyclonal Goat IgG

Purification

Antigen Affinity-purified

Immunogen

E. coli-derived recombinant human Otoraplin/OTOR
Val18-Glu128
Accession # Q9NRC9

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Otoraplin/OTOR

Otoraplin (OTOR), also known as fibrocyte-derived protein (Fdp) and Melanoma inhibitory activity-like (MIAL), is a secreted 16 kDa globular protein that is preferentially expressed in the inner ear by periotic mesenchyme and developing and mature fibrocytes. It is highly homologous to MIA/cartilage-derived retinoic acid‑sensitive protein (CD-RAP), which is a cartilage-specific protein that is also expressed in malignant melanoma cells. The 111 amino acid residue (aa) mature human otoraplin contains one SH3 domain (aa 46‑107) and a Tyr at position 50 that is reportedly sulfated. Otoraplin is reported to play a role in the initiation of periotic mesenchyme chondrogenesis. Mature human Otoraplin shares 91% and 89% aa sequence identity with canine and mouse Otoraplin, respectively.

Entrez Gene IDs

56914 (Human); 57329 (Mouse); 366206 (Rat)

Alternate Names

FDPMelanoma inhibitory activity-like protein; Fibrocyte-derived protein; MGC126739; MIAL1; MIALMGC126737; OTOR; Otoraplin