Human/Mouse/Rat CDC14 Alexa Fluor® 750-conjugated Antibody

Catalog #: FAB4457S Datasheet / COA / SDS

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FAB4457S-100UG

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Human/Mouse/Rat CDC14 Alexa Fluor® 750-conjugated Antibody Summary

Species Reactivity

Human, Mouse, Rat

Specificity

Detects endogenous human, mouse and rat CDC14A in Western blots. In Western blots, this antibody does not cross‑react with recombinant human PTEN. Reactivity with CDC14B is not known.

Source

Monoclonal Mouse IgG1 Clone # 472508

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human CDC14A
Met15-Gly366
Accession # Q9UNH5

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 750 (Excitation= 749 nm, Emission= 775 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: CDC14

Cell Division Cycle 14 (CDC14) is a dual tyrosine and serine/threonine phosphatase. There are two CDC14 proteins, CDC14A with a molecular weight of 70 kDa, and CDC14B with a molecular weight of 53 kDa. CDC14A is primarily associated with the nucleolus, bound to Cfi1/Net1 during cell cycle interphase. During anaphase and telophase, CDC14 redistributes to the nucleoplasm and cytoplasm, where it plays a role in segregating and separating sister chromatids. Mutations that alter CDC14 function cause uneven distribution of chromosomes in dividing cells.

Long Name

Cell Division Cycle 14

Entrez Gene IDs

8556 (Human); 229776 (Mouse); 310806 (Rat)

Alternate Names

CDC14; cdc14;CDC14A;DFNB105;DFNB32;DFNB35;Dual specificity protein phosphatase CDC14A;hCDC14; CDC14A