Human/Mouse/Rat FKBP13 Alexa Fluor® 405-conjugated Antibody

Catalog #: AF4356V Datasheet / COA / SDS

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AF4356V-100UG

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Human/Mouse/Rat FKBP13 Alexa Fluor® 405-conjugated Antibody Summary

Species Reactivity

Human, Mouse, Rat

Specificity

Detects endogenous human, mouse, and rat FKBP13 in Western blots. In Western blots, this antibody does not cross‑react with recombinant human FKBP12, FKBP25, FKBP38, FKBP51 or FKBP52.

Source

Polyclonal Sheep IgG

Purification

Antigen Affinity-purified

Immunogen

E. coli-derived recombinant human FKBP13
Ala22-Leu142
Accession # P26885

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 405 (Excitation= 405 nm, Emission= 421 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: FKBP13

FK506 binding protein, 13 kilodalton molecular weight (FKBP13), also called FKBP2, is a peptidyl-prolyl isomerase that catalyzes the transition between cis- and trans‑proline residues critical for proper folding of proteins. The immunosuppressants FK506 and rapamycin are potent inhibitors of FKBP13. This isomerase is localized in the endoplasmic reticulum and is also associated with cytoskeletal elements such as erythrocyte band 4.1. FKBP13 levels are increased by treatments that affect golgi protein processing such as tunicamycin and heat shock, suggesting that FKBP13 is important in the unfolded protein response observed with endoplasmic reticulum stress.

Long Name

13 kDa FK506 Binding Protein

Entrez Gene IDs

2286 (Human); 14227 (Mouse); 25639 (Rat)

Alternate Names

EC 5.2.1.8,13 kDa FK506-binding protein; FK506 binding protein 2, 13kDa; FK506-binding protein 2 (13kD); FK506-binding protein 2; FKBP13; FKBP13,13 kDa FKBP; FKBP-13proline isomerase; FKBP2; FKBP-2; Immunophilin FKBP13; peptidyl-prolyl cis-trans isomerase FKBP2; PPIase FKBP2; PPIase; rapamycin-binding protein; rotamase