Human/Mouse/Rat GDF-11/GDF-8 Alexa Fluor® 405-conjugated Antibody

Catalog #: FAB788V Datasheet / COA / SDS

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FAB788V-100UG

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Human/Mouse/Rat GDF-11/GDF-8 Alexa Fluor® 405-conjugated Antibody Summary

Species Reactivity

Human, Mouse, Rat

Specificity

Detects human, mouse, and rat GDF-8 in direct ELISAs and Western blots. In Western blots, this antibody shows approximately 30% cross-reactivity with recombinant human/mouse/rat GDF-11. In direct ELISAs, this antibody shows less than 1

Source

Monoclonal Rat IgG2b Clone # 84214

Purification

Protein A or G purified

Immunogen

Mouse myeloma cell line NS0-derived recombinant mouse GDF-8
Asn25-Ser376
Accession # O08689

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 405 (Excitation= 405 nm, Emission= 421 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: GDF-8/Myostatin

GDF-8, also known as Myostatin, belongs to the TGF-beta superfamily. It is synthesized as an inactive proprotein with the N-terminal pro-region and the C-terminal mature bioactive region. The GDF-8 proregion is capable of associating with active GDF-8 with high affinity and is a potent GDF-8 antagonist.

Long Name

Growth Differentiation Factor 8

Entrez Gene IDs

2660 (Human); 17700 (Mouse)

Alternate Names

GDF8; GDF-8; GDF8growth differentiation factor 8; growth/differentiation factor 8; MSLHP; MSTN; Myostatin